1-CBZ-3-羟甲基吡咯烷合成路线 （共 10 条）
反应条件
sodium tetrahydroborate
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/26165 A1, 2005 ;
Location in patent: Page/Page column 136-137 ;
反应条件
triethylamine in dichloromethane T=-60 - 20°C; 16 h;
参考文献
Rodriguez-Lucena, David; Morin, Marie S.T.; Compain, Philippe
Letters in Organic Chemistry, 2011 , vol. 8, # 3 p. 155 - 162
反应条件
1: 85 percent / CHCl3 2: 56 percent / NaBH4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2150 - 2155
反应条件
1: 85 percent / CHCl3 2: 56 percent / NaBH4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 8 p. 2150 - 2155
反应条件
1: 10 palladium on activated charcoal; hydrogen / methanol / 48 h 2: triethylamine / dichloromethane / 16 h / -60 - 20 °C View Scheme
参考文献
Letters in Organic Chemistry, , vol. 8, # 3 p. 155 - 162
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 50 °C 2: 10 palladium on activated charcoal; hydrogen / methanol / 48 h 3: triethylamine / dichloromethane / 16 h / -60 - 20 °C View Scheme
参考文献
Letters in Organic Chemistry, , vol. 8, # 3 p. 155 - 162
反应条件
1: methanol / 16 h 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 50 °C 3: 10 palladium on activated charcoal; hydrogen / methanol / 48 h 4: triethylamine / dichloromethane / 16 h / -60 - 20 °C View Scheme
参考文献
Letters in Organic Chemistry, , vol. 8, # 3 p. 155 - 162
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/26165 A1, 2005 ;
Location in patent: Page/Page column 137 ;
反应条件
hydrogenchloride; sodium hydroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine in methanol; tetrahydrofuran-water; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Merck and Co., Inc.
Patent: US6329380 B1, 2001 ;
US 6329380 B1
反应条件
triethylamine in dichloromethane
3 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2005/49605 A1, 2005 ;
Location in patent: Page/Page column 156 ;
