1: 55 percent / NaOCH2Ph / 24 h / Heating 2: 83 percent / (CF3-CO)2O / toluene / 20 °C 3: H2; 10 percent Pd/C / ethyl acetate View Scheme

1: 84 percent / NaOMe / 24 h / Heating 2: 77 percent / (CF3-CO)2O / toluene / 20 °C View Scheme

1: sulfuryl chloride / diethyl ether / 16 h / 25 °C 2: 98 percent / potassium carbonate / acetone / 21 h / Heating 3: 66 percent / boron trichloride / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 4 h 4: 88 percent / potassium carbonate / acetone / 22 h / Heating 5: 80 percent / potassium hydroxide / dimethylsulfoxide / 4.5 h / 90 - 100 °C View Scheme