二苯并[b,f][1,4]硫氮杂卓-11-[10H]酮合成路线 （共 38 条）
反应条件
1: methanol. sodium methylate 2: ethyl acetate; Raney nickel / Hydrogenation 3: 220 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 42, p. 1265,1269,1272
反应条件
n-butyllithium 1) ether, room temperature, 30 h, 2) ether; Yield given. Multistep reaction;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 6 p. 581 - 582
反应条件
oxygen in benzene 2 h; Irradiationother solvents; without oxygen.; Product distribution;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 58, # 11 p. 3131 - 3136
反应条件
titanium tetrachloride in 1,4-dioxane; toluene T=50 - 100°C;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2006/107948 A2, 2006 ;
Location in patent: Page/Page column 77-78 ;
WO 2006/107948 A2
反应条件
T=170°C; 5 h; Heating / reflux;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
反应条件
1: trichlorophosphate / N,N-dimethyl-aniline; dichloromethane 2: triethylamine / tetrahydrofuran; toluene View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
T=170°C; 5.5 h; Heating / reflux;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 17-18 ;
反应条件
T=170°C; 5 h; Heating / reflux;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 16-17 ;
反应条件
pentan-1-ol T=160°C; 32 h; Heating / reflux; Product distribution / selectivity;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 15 ;
反应条件
T=170 - 200°C; 6 - 20 h; Heating / reflux; Product distribution / selectivity;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 12-15 ;
