二苯并[b,f][1,4]硫氮杂卓-11-[10H]酮合成路线 （共 38 条）
反应条件
1: POCl3; N,N-dimethylaniline / 4 h / Heating 2: xylene / Heating View Scheme
参考文献
Warawa; Migler; Ohnmacht; Needles; Gatos; McLaren; Nelson; Kirkland
Journal of Medicinal Chemistry, 2001 , vol. 44, # 3 p. 372 - 389
反应条件
T=170 - 200°C; 6 - 20 h; Heating / reflux; Product distribution / selectivity;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 12-15 ;
反应条件
N,N-dimethyl-aniline; trichlorophosphate T=106°C; 6 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2007/62339 A2, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
phosphorus pentachloride; nitrogen in dichloromethane
参考文献
Kansal, Vinod Kumar; Ahmad, Suhail; Lal, Kanhaiya; Patil, Bhatu Tumba
Patent: US2008/241949 A1, 2008 ;
反应条件
tetraphosphorus decasulfide in pyridine 6.5 h; Heating;
参考文献
Polivka; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1465 - 1476
反应条件
T=170°C; 5.5 h; Heating / reflux;
参考文献
UNION QUIMICO-FARMACEUTICA S.A.
Patent: WO2006/94549 A1, 2006 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: POCl3; N,N-dimethylaniline / 4 h / Heating 2: xylene / Heating View Scheme
参考文献
Warawa; Migler; Ohnmacht; Needles; Gatos; McLaren; Nelson; Kirkland
Journal of Medicinal Chemistry, 2001 , vol. 44, # 3 p. 372 - 389
反应条件
1: 10,11-dihydro-11-oxodibenz[b,f][1,4]thiazepine With trichlorophosphate in toluene
T=10°C; 4 h; Heating / reflux;
2: With potassium carbonate in water; toluene
T=15°C;
3: piperazine With hydrogenchloride
more than 3 stages;
参考文献
USV LIMITED
Patent: WO2007/4234 A1, 2007 ;
Location in patent: Page/Page column 12 ;
