反应条件
in diethyl ether (N2); addn. of 1 equiv. of MeLi to soln. of 2-methylpyridine in ether; reflux for 30 min; cooling to room temp.; stirring for 1 h; cooling to -78°C; addn. of Me3GeCl (1.2 equiv.); stirring at room temp. for 1 h; quenching with H2O; extn. into ether; washing with NaOH; washing of ether layer with H2O; drying (MgSO4); removal of solvent under reduced pressure; dry-flash chromy. (petroleum spirits/ether);
参考文献
Karnezis, Asimo; O'Hair, Richard A. J.; White, Jonathan M.
Organometallics, 2009 , vol. 28, # 22 p. 6480 - 6488