2,2-二甲基-1-(2-吡啶基)-1-丙酮合成路线 （共 9 条）
反应条件
1: 2-bromo-pyridine With n-butyllithium in diethyl ether T=-78°C; 1.5 h; Inert atmosphere; 2: 2,2-dimethyl-1-propanenitrile in diethyl ether T=-78 - 20°C; Inert atmosphere;
参考文献
Diaz-Valenzuela, M. Belen; Phillips, Scott D.; France, Marcia B.; Gunn, Mary E.; Clarke, Matthew L.
Chemistry - A European Journal, 2009 , vol. 15, # 5 p. 1227 - 1232
反应条件
1: in diethyl ether T=-15 - 20°C; 4 h; 2: With hydrogenchloride in diethyl ether T=20°C; 0.25 h;
参考文献
Easmon, Johnny; Puerstinger, Gerhard; Thies, Katrin-Sofia; Heinisch, Gottfried; Hofmann, Johann
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6343 - 6350
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: pivalaldehyde in tetrahydrofuran; hexane T=-78°C; 1 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 5 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
参考文献
Abarca, Belen; Asensio, Amparo; Ballesteros, Rafael; Bosch, Jordi; Jones, Gurnos; et al.
Journal of Chemical Research, Miniprint, 1990 , # 1 p. 347 - 354
反应条件
potassium hydroxide in toluene 40 h; Ambient temperature;
参考文献
Rubina, K.; Goldberg, Yu.; Shymanska, M.
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2489 - 2500
反应条件
1: 46 percent / 17 h / Ambient temperature 2: 51 percent / NaN(SiMe3)2 / tetrahydrofuran / 2 h / -80 °C View Scheme
参考文献
Anders, Ernst; Boldt, Hans Guenter; Clark, Timothy; Fuchs, Renate; Gassner, Thomas
Chemische Berichte, 1986 , vol. 119, # 1 p. 279 - 296
反应条件
1: 46 percent / 17 h / Ambient temperature 2: 51 percent / NaN(SiMe3)2 / tetrahydrofuran / 2 h / -80 °C View Scheme
参考文献
Anders, Ernst; Boldt, Hans Guenter; Clark, Timothy; Fuchs, Renate; Gassner, Thomas
Chemische Berichte, 1986 , vol. 119, # 1 p. 279 - 296
反应条件
in diethyl ether T=-78°C;
参考文献
Falorni, Massimo; Giacomelli, Giampaolo
Gazzetta Chimica Italiana, 1992 , vol. 122, # 8 p. 339 - 340
反应条件
Yield given. Multistep reaction;
参考文献
Zadel, Guido; Breitmaier, Eberhard
Angewandte Chemie, 1992 , vol. 104, # 8 p. 1070 - 1071
