N-苄氧羰基-L-异亮氨酸合成路线 （共 29 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane 2: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 3: dichloromethane View Scheme
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
反应条件
1: camphorsulfonic acid / benzene 2: CF3CO2H; Et3SiH View Scheme
参考文献
Hughes, Andrew B.; Sleebs, Brad E.
Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637
反应条件
sodium hydride in tetrahydrofuran 1.) 0 deg C, 15 min, 2.) r.t., 28 h; Yield given;
参考文献
Pettit; Singh; Srirangam; Hogan-Pierson; Williams
Journal of Organic Chemistry, 1994 , vol. 59, # 7 p. 1796 - 1800
反应条件
1: N-CBZ-L-isoleucine With bis(trichloromethyl) carbonate; triethylamine in dichloromethane T=0°C; 2: 1-hydroxy-pyrrolidine-2,5-dione in dichloromethane T=20°C; 0.5 h;
参考文献
Kim, Misoo; Han, Ki-Jong
Synthetic Communications, 2009 , vol. 39, # 24 p. 4467 - 4472
反应条件
1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; 5 h;
参考文献
Samai, Suman; Dey, Joykrishna; Biradha, Kumar
Soft Matter, 2011 , vol. 7, # 5 p. 2121 - 2126
反应条件
pyridine in acetonitrile
参考文献
Griffin, Martin; Mongeot, Alexandre; Collighan, Russell; Saint, Robert E.; Jones, Richard A.; Coutts, Ian G.C.; Rathbone, Daniel L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5559 - 5562
反应条件
1: camphorsulfonic acid / benzene 2: CF3CO2H; Et3SiH 3: H2 / Pd/C / ethanol View Scheme
参考文献
Aurelio, Luigi; Brownlee, Robert T. C.; Dang, Jason; Hughes, Andrew B.; Polya, Gideon M.
Australian Journal of Chemistry, 2006 , vol. 59, # 6 p. 407 - 414
参考文献
Colonna, Stefano; Molinari, Henriette; Banfi, Stefano; Julia, Sebastian; Masana, Jaume; Alvarez, Angel
Tetrahedron, 1983 , vol. 39, # 9 p. 1635 - 1642
反应条件
ethylenediaminetetraacetic acid; phenyl-methyl-sulfonyl fluoride; water in aq. phosphate buffer T=30°C; Microbiological reactionEnzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Maurs, Michele; Acher, Francine; Azerad, Robert
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 22 - 26
反应条件
1: 92 percent / DIEA, TBTU, HOBt / acetonitrile / 21 h / Ambient temperature 2: LiOH-H2O / tetrahydrofuran; methanol; H2O / 1.25 h / Ambient temperature View Scheme
参考文献
Lehmann, Juerg; Linden, Anthony; Heimgartner, Heinz
Tetrahedron, 1998 , vol. 54, # 30 p. 8721 - 8736
