2-乙酰氨基-5-甲氧基甲苯合成路线 （共 33 条）
反应条件
pyridine T=0 - 20°C; Inert atmosphere;
参考文献
Thompson, Sam; Vallinayagam, Ramakrishnan; Adler, Marc J.; Scott, Richard T.W.; Hamilton, Andrew D.
Tetrahedron, 2012 , vol. 68, # 23 p. 4501 - 4505
反应条件
acetic anhydride in dimethylammonium 2,4-dichlorophenoxyacetate
参考文献
Zeneca Limited
Patent: US6184225 B2, 2001 ;
反应条件
acetic anhydride; triethylamine in dichloromethane
参考文献
MITSUBISHI TANABE PHARMA CORPORATION
Patent: US2012/196824 A1, 2012 ;
反应条件
triethylamine in tetrahydrofuran T=0 - 25°C; 4.08333 h;
参考文献
WO2006/52555 A2, ;
Page/Page column 33; 74 ;
反应条件
boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene T=20°C; 2 h; regioselective reaction;
参考文献
Liu, Huan; Wang, Xuemin; Gu, Yonghong
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1614 - 1620
反应条件
1: 83 percent / aluminium chloride / benzene / 0.5 h / Heating 2: 34 percent / nitric acid, acetic acid / 4 h / 15 - 16 °C / further nitration agents 3: 97 percent / potassium carbonate / dimethylformamide / 14 h / Ambient temperature 4: 1.) hydrogen / 1.) palladized charcoal / 1.) ethanol, 18 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1613 - 1620
反应条件
1: 34 percent / nitric acid, acetic acid / 4 h / 15 - 16 °C / further nitration agents 2: 97 percent / potassium carbonate / dimethylformamide / 14 h / Ambient temperature 3: 1.) hydrogen / 1.) palladized charcoal / 1.) ethanol, 18 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1613 - 1620
反应条件
1: 77 percent / bromine, aluminium powder 2: 83 percent / aluminium chloride / benzene / 0.5 h / Heating 3: 34 percent / nitric acid, acetic acid / 4 h / 15 - 16 °C / further nitration agents 4: 97 percent / potassium carbonate / dimethylformamide / 14 h / Ambient temperature 5: 1.) hydrogen / 1.) palladized charcoal / 1.) ethanol, 18 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1613 - 1620
参考文献
Chemische Berichte, , vol. 49, p. 965
Journal of the American Chemical Society, , vol. 41, p. 1457
反应条件
1: 97 percent / potassium carbonate / dimethylformamide / 14 h / Ambient temperature 2: 1.) hydrogen / 1.) palladized charcoal / 1.) ethanol, 18 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 7 p. 1613 - 1620
