4-氯-8-三氟甲基喹啉-3-羧酸乙酯合成路线 （共 5 条）
反应条件
1: With trichlorophosphate 12 h; Heating / reflux; 2: With sodium hydroxide in water
参考文献
YUNGJIN PHARMACEUTICAL CO., LTD.
Patent: WO2008/93940 A1, 2008 ;
Location in patent: Page/Page column 67-69 ;
WO 2008/093940 A1
参考文献
Hu, Baihua; Bernotas, Ron; Unwalla, Rayomand; Collini, Michael; Quinet, Elaine; Feingold, Irene; Goos-Nilsson, Annika; Wilhelmsson, Anna; Nambi, Ponnal; Evans, Mark; Wrobel, Jay
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 689 - 693
反应条件
1.1: 120 - 150 °C 1.2: Heating 2.1: POCl3 View Scheme
参考文献
Zask; Gu; Albright; Du; Hogan; Levin; Chen; Killar; Sung; DiJoseph; Sharr; Roth; Skala; Jin; Cowling; Mohler; Barone; Black; March; Skotnicki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 8 p. 1487 - 1490
反应条件
1.1: 120 - 150 °C 1.2: Heating 2.1: POCl3 View Scheme
参考文献
Zask; Gu; Albright; Du; Hogan; Levin; Chen; Killar; Sung; DiJoseph; Sharr; Roth; Skala; Jin; Cowling; Mohler; Barone; Black; March; Skotnicki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 8 p. 1487 - 1490
反应条件
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C
2.1: dimethyl sulfoxide; oxalyl dichloride; triethylamine / dichloromethane / 3 h / -78 - 20 °C
3.1: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 20 h / |Reflux
4.1: bis(η3-allyl-μ-chloropalladium(II)); 1-(2,6-diisopropylphenyl)-3-(2-(phenylthio)phenyl)-4,5-dihydro-imidazolium chloride; caesium carbonate / 1,4-dioxane / 1 h / 100 °C / |Inert atmosphere
4.2: 15 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Kuriyama, Masami; Hamaguchi, Norihisa; Sakata, Keisuke; Onomura, Osamu
European Journal of Organic Chemistry, 2013 , # 16 p. 3378 - 3385
