2-(4-溴丁氧基)四氢-2H-吡喃合成路线 （共 24 条）
反应条件
pyridinium p-toluenesulfonate in dichloromethane T=20°C; 24 h;
参考文献
Bouder, Thomas Le; Viau, Lydie; Guegan, Jean-Paul; Maury, Olivier; Bozec, Hubert Le
European Journal of Organic Chemistry, 2002 , # 17 p. 3024 - 3033
反应条件
tetrabutylammomium bromide; chlorodimethyl(phenylthio)chloride methanaminium; triethylamine in dichloromethane T=20°C; Bromination;
参考文献
Gomez; Gellibert; Wagner; Mioskowski
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6049 - 6052
反应条件
1: With trimethylsilyl bromide in dichloromethane Ring cleavage; 16 h; Heating; 2: With toluene-4-sulfonic acid in dichloromethane T=20°C; Addition; 4 h; Further stages.;
参考文献
Qin, Donghui; Sullivan, Regina; Berkowitz, William F.; Bittman, Robert; Rotenberg, Susan A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1413 - 1417
反应条件
2: CBr3, PPh3 View Scheme
参考文献
Yadav; Sengupta, Sandip
European Journal of Organic Chemistry, 2013 , # 2 p. 376 - 388
反应条件
carbon tetrabromide; triphenylphosphine
参考文献
Smallheer, Joanne M.; McHugh, Robert J.; Chang, Chong-Hwan; Kaltenbach III, Robert F.; Worley, Tabitha V.; Klabe, Ronald M.; Bacheler, Lee T.; Rayner, Marlene M.; Erickson-Viitanen, Susan; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 11 p. 1365 - 1370
反应条件
hydrogen bromide 1.) MeOH, 2.) hexane, to 60-62 deg C, 3 h,;
参考文献
Joshi, N. N.; Mamdapur, V. R.; Chada, M. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 3 p. 231 - 235
反应条件
1: 56 percent / Li2CuCl4 / tetrahydrofuran / 3 h / -10 °C 2: 52 percent / pyridinium p-toluenesulfonate / methanol / 6 h / 55 °C View Scheme
参考文献
Trehan; Vig; Singh; Sharma; Kad
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 6 p. 518 - 520
反应条件
dilithium tetrachlorocuprate; magnesium 1.) THF, 2 h, 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Michelot, Didier
Synthesis, 1983 , # 2 p. 130 - 134
反应条件
1: 1.) Mg, 2.) dilithium tetrachlorocuprate / 1.) THF, 2 h, 2.) 0 deg C, 2 h 2: 1.) Li/NH3 liq. / 2.) DMSO, gentle warming, 2h View Scheme
参考文献
Michelot, Didier
Synthesis, 1983 , # 2 p. 130 - 134
反应条件
sodium; toluene-4-sulfonic acid Yield given. Multistep reaction;
参考文献
Lin, Chu-Chung; Hsia, Ket-Shang; Wu, Hsien-Jen
Journal of the Chinese Chemical Society (Taipei, Taiwan), 1993 , vol. 40, # 6 p. 587 - 592
