2-乙炔-1-吡咯烷羧酸-1,1-二甲基乙酯合成路线 (共 2 条)
反应条件
1: 2-[(methoxymethylamino) carbonyl]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester With diisobutylaluminium hydride in n-heptane; dichloromethane T=-78°C; 1.25 h; 2: With methanol in n-heptane; dichloromethane 3: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With water; potassium carbonate; Sodium potassium tartrate more than 3 stages;
参考文献
IDENIX PHARMACEUTICALS, INC.
Patent: WO2009/14730 A1, 2009 ;
Location in patent: Page/Page column 114-115 ;
WO 2009/014730 A1
反应条件
potassium carbonate in methanol T=20°C; 15 h;
参考文献
Alcaide, Benito; Almendros, Pedro; Quiros, M. Teresa; Fernandez, Israel
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 818 - 826