N-(4-溴苯基)-3-苯基丙酰氨合成路线 (共 4 条)
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/14940 A2, 2007 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: 4-bromo-aniline With 2-(4-formyl-3-methoxyphenoxy)ethyl polystyrene; sodium tris(acetoxy)borohydride; trimethyl orthoformate in 1,2-dichloro-ethane T=20°C; 20 h; 2: 3-phenylpropionic acid With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 24 h; 3: With trifluoroacetic acid in dichloromethane 20 h;
参考文献
Tao, Bin; Boykin, David W.
Journal of Chemical Research - Part S, 2003 , # 1 p. 10 - 11
反应条件
trichlorophosphate
T=10 - 80°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/435 A1, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=10°C;
2: N-(4-bromophenyl)-3-phenylpropanamide T=20 - 80°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/434 A1, 2007 ;
Location in patent: Page/Page column 36-37 ;