1: 90 percent / 4-chlorophenyl dichlorophosphate / pyridine / 72 h / Ambient temperature 2: 60 percent / aq. NH3 / dioxane / 1 h / Ambient temperature 3: 0.4 g / conc. aq. NH3 / dioxane / 12 h / 55 °C View Scheme

1: 1.) N,O-bis(trimethylsilyl)acetamide (BSA), 2.) (trimethylsilyl)methyl trifluoromethanesulfonate (TMS-triflate) / 1.) 1,2-dichloroethane, reflux, 30 min, 2.) 1,2-dichloroethane, reflux, 4 h 2: 76 percent / 28percent aq. ammonia, pyridine / 24 h / 50 °C View Scheme

ammonia

1: 1.) N,O-bis(trimethylsilyl)acetamide (BSA), 2.) (trimethylsilyl)methyl trifluoromethanesulfonate (TMS-triflate) / 1.) 1,2-dichloroethane, reflux, 30 min, 2.) 1,2-dichloroethane, reflux, 4 h 2: 69 percent / 28percent aq. ammonia, pyridine / 24 h / 50 °C View Scheme