6-氨基烟酸合成路线

参考文献

Zhang, Guangtao; Plotnikov, Alexander N.; Rusinova, Elena; Shen, Tong; Morohashi, Keita; Joshua, Jennifer; Zeng, Lei; Mujtaba, Shiraz; Ohlmeyer, Michael; Zhou, Ming-Ming
Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 9251 - 9264

110-91-8吗啉+

3167-49-56-氨基烟酸

827587-90-6(6-氨基吡啶-3-基)-吗啉-4-基甲酮

参考文献

MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
Location in patent: Page/Page column 173 ;

3167-49-56-氨基烟酸

89488-06-26-氨基-5-硝基-3-吡啶羧酸

参考文献

Iwata, Hidehisa; Kohara, Yasuhisa; Cao, Sheldon X.; Guntupalli, Prasuna; Gwaltney, Stephen L.; Hosfield, David J.; Liu, Yan; Stafford, Jeffrey A.; Throop, Beverly
Patent: US2010/69431 A1, 2010 ;
Location in patent: Page/Page column 24 ;

3167-49-56-氨基烟酸+

100-39-0溴化苄

935687-49-3苄基 6-氨基烟酸

参考文献

PFIZER INC.; BENBOW, John William; LOU, Jihong; PFEFFERKORN, Jeffrey Allen; TU, Meihua Mike
Patent: WO2010/29461 A1, 2010 ;
Location in patent: Page/Page column 65-66 ;
WO 2010/029461 A1

3167-49-56-氨基烟酸+

100-51-6苯甲醇

935687-49-3苄基 6-氨基烟酸

参考文献

Pfizer Inc
Patent: US2010/184777 A1, 2010 ;
Location in patent: Page/Page column 15 ;
US 20100184777 A1

3167-49-56-氨基烟酸+

100-51-6苯甲醇

405939-48-2苄基(6-氨基-5-溴-3-吡啶基)氨基甲酸酯+

35486-42-12-氨基-3,5-二溴吡啶

参考文献

Kuo, Gee-Hong; Prouty, Catherine; Wang, Aihua; Emanuel, Stuart; DeAngelis, Alan; Zhang, Yan; Song, Fengbin; Beall, Lawrence; Connolly, Peter J.; Karnachi, Prahba; Chen, Xin; Gruninger, Robert H.; Sechler, Jan; Fuentes-Pesquera, Angel; Middleton, Steven A.; Jolliffe, Linda; Murray, William V.
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