3-硝基-4-甲氧基苯甲醛合成路线 （共 45 条）
反应条件
1: methanolic NaOH-solution / 0 °C 2: concentrated hydrochloric acid View Scheme
参考文献
Jacobs; Heidelberger
Journal of Biological Chemistry, 1915 , vol. 20, p. 674
反应条件
1: NaBH4 2: PBr3 View Scheme
参考文献
Synthesis, , # 3 p. 405 - 410
反应条件
1: 0.33 h / Heating 2: sodium borohydride / ethanol / 24 h / Ambient temperature 3: 12 N HCl / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson
Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494
反应条件
1.1: 100 percent / sodium acetate / 0.08 h / microwave irradiation 2.1: NaOH / 90 °C 2.2: 80 percent / H2O2 3.1: 85 percent / hydrogen / palladium catalyst / methanol / 25 °C / 2327.17 Torr 4.1: sodium nitrite; sulfuric acid / acetic acid / 0 °C 4.2: 86 percent / sodium azide / acetic acid / 0.5 h / 20 °C 5.1: 80 percent / dicyclohexylcarbodiimide; Et3N / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Rodrigues, J. Augusto R.; Abramovitch, Rudolph A.; De Sousa, Joana D. F.; Leiva, Genaro C.
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 2920 - 2928
反应条件
1: diethyl 1-ethoxycarbonylpropylphosphonate With sodium hydride in tetrahydrofuran 1 h; 2: 3-Nitro-4-methoxybenzaldehyde in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
Nomura, Masahiro; Tanase, Takahiro; Ide, Tomohiro; Tsunoda, Masaki; Suzuki, Masahiro; Uchiki, Hideharu; Murakami, Koji; Miyachi, Hiroyuki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 17 p. 3581 - 3599
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -23 °C
1.2: 66 percent / tetrahydrofuran; hexane / 21 h / -23 - 20 °C
2.1: 63 percent / NiCl2*6H2O; NaBH4 / methanol / 0.5 h / 20 °C
View Scheme
参考文献
Liu, Ying-Qian; Li, Xiao-Jing; Zhao, Chun-Yan; Nan, Xiang; Tian, Jing; Morris-Natschke, Susan L.; Zhang, Zhi-Jun; Yang, Xiao-Ming; Yang, Liu; Li, Lin-Hai; Zhou, Xing-Wen; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1248 - 1256
反应条件
sodium hydride in tetrahydrofuran; mineral oil
1 h; Reflux;
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
Location in patent: Page/Page column 69 ;
US 20120015962 A1
反应条件
1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / Reflux
2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 20 °C
View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
diethyl ether
unter Kuehlung und Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit CrO3 in Essigsaeure;
参考文献
Berlingozzi
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1934 , vol. <6>19, p. 332,336
反应条件
1: potassium permanganate
2: durch Nitrierung
View Scheme
参考文献
de Lange
Recueil des Travaux Chimiques des Pays-Bas, 1926 , vol. 45, p. 45
