3-硝基-4-甲氧基苯甲醛合成路线 （共 45 条）
反应条件
in ethanol; dichloromethane
1 h;
参考文献
Blokhin, A.V.; Bundel, Yu. G.; Terenin, V.I.; Kurtz, A.L.
Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, # 11 p. 2116 - 2123
Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 11 p. 2399 - 2406
反应条件
1.1: nBuLi / tetrahydrofuran / 4 h / 20 °C
1.2: 31 percent / tetrahydrofuran / 18 h
2.1: 77 percent / Zn; AcOH / 1.5 h
View Scheme
参考文献
Pettit, George R.; Anderson, Collin R.; Herald, Delbert L.; Katherine Jung; Lee, Debbie J.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 525 - 531
反应条件
1.1: sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C / Inert atmosphere
2.1: phosphorus tribromide / toluene / 0.5 h / 40 - 100 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 3 h / 20 °C / Inert atmosphere
4.1: dihydrogen peroxide; acetic acid / water / 24 h / 20 °C / Inert atmosphere
5.1: acetic acid; benzylamine / Inert atmosphere; Reflux
6.1: sodium dithionite / water; acetone / 1 h / 50 °C / Inert atmosphere
7.1: sodium acetate / methanol / 0.17 h / Inert atmosphere; Reflux
7.2: Inert atmosphere; Reflux
8.1: water; sodium hydroxide / ethanol / Inert atmosphere
View Scheme
参考文献
Reddy, M. V. Ramana; Venkatapuram, Padmavathi; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Robell, Kimberly A.; Akula, Balaiah; Hoffman, Benjamin S.; Reddy, E. Premkumar
Journal of Medicinal Chemistry, 2011 , vol. 54, # 18 p. 6254 - 6276
反应条件
1.1: 100 percent / sodium acetate / 0.08 h / microwave irradiation
2.1: NaOH / 90 °C
2.2: 80 percent / H2O2
View Scheme
参考文献
Rodrigues, J. Augusto R.; Abramovitch, Rudolph A.; De Sousa, Joana D. F.; Leiva, Genaro C.
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 2920 - 2928
反应条件
1.1: 100 percent / sodium acetate / 0.08 h / microwave irradiation
2.1: NaOH / 90 °C
2.2: 80 percent / H2O2
3.1: 85 percent / hydrogen / palladium catalyst / methanol / 25 °C / 2327.17 Torr
View Scheme
参考文献
Rodrigues, J. Augusto R.; Abramovitch, Rudolph A.; De Sousa, Joana D. F.; Leiva, Genaro C.
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 2920 - 2928
