2-(3-丁烯)丙二酸二乙酯合成路线 （共 12 条）
反应条件
1: diethyl malonate With sodium ethanolate in ethanol T=20°C; 0.5 h; 2: 4-bromo-but-1-ene in ethanol Reflux;
参考文献
Yip, Kai-Tai; Zhu, Nian-Yong; Yang, Dan
Organic Letters, 2009 , vol. 11, # 9 p. 1911 - 1914
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran T=0 - 20°C; 1 h; Inert atmosphere; 2: 4-bromo-but-1-ene T=20°C; 12 h;
参考文献
Kotha, Sambasivarao; Shirbhate, Mukesh E.
Synlett, 2012 , vol. 23, # 15 p. 2183 - 2188
参考文献
Linstead; Rydon
Journal of the Chemical Society, 1934 , p. 1998
反应条件
hydrogenchloride; Na[CpFe(CO)2] Yield given. Multistep reaction;
参考文献
Abram, Trevor S.; Baker, Raymond; Exon, Christopher; Rao, V. Bhaskar
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 285 - 294
参考文献
Drinkwater; Smith
Journal of the Chemical Society. Perkin transactions 1, 1971 , vol. 7, p. 1305 - 1307
反应条件
1: 85 percent / LiCl / dimethylsulfoxide 2: 75 percent / diethyl ether / 40 h / Ambient temperature 3: 1.) hexamethyldisilazane, 2.) 0.2 N NaOH / 1.) dichloromethane, reflux, 24 h, 2.) 48 h 4: 72 percent / potassium hydroxide / H2O / 2 h / 100 °C 5: 63 percent / sodium, liquid ammonia / tetrahydrofuran View Scheme
参考文献
Deleris; Dunogues; Gadras
Tetrahedron, 1988 , vol. 44, # 13 p. 4243 - 4258
反应条件
1: 76 percent / DMSO; NaCl 2: 93 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Konstantinovic; Predojevic; Gojkovic; Ratkovic; Dimitrijevic; Mojsilovic
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 9 p. 802 - 805
反应条件
lithium chloride in dimethyl sulfoxide
参考文献
Deleris; Dunogues; Gadras
Tetrahedron, 1988 , vol. 44, # 13 p. 4243 - 4258
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20 - 50°C; 2: With sodium hydroxide; water in tetrahydrofuran pH=10;
参考文献
US2007/197615 A1, ;
Page/Page column 5 ;
反应条件
1: (i) EtONO, (ii) NaOEt
2: (i) Al-Hg, (ii) aq. NaOH
View Scheme
参考文献
Drinkwater; Smith
Journal of the Chemical Society. Perkin transactions 1, 1971 , vol. 7, p. 1305 - 1307
