1: With sodium hydroxide; sodium nitrite in water Cooling with ice; 2: With sulfuric acid in water T=0°C; 0.166667 h; 3: With hydrogenchloride; SnCl2·2H2O in water T=0°C; 1 h;
参考文献
Pfizer Inc.
Patent: US2011/28447 A1, 2011 ;
Location in patent: Page/Page column 40 ;
1: 1) 10M NaOH 2) 30percent aq. H2O2 / 1) 70 deg C, 60 min 2) 70 deg C, 60 min 2: 1) 48percent HBr, NaNO2 2) CuBr / 1) water, 1 h, 0 deg C 2) a) 30 min, r.t. b) 90 min, 70 deg C 3: SOCl2 / CH2Cl2 / 1 h / Heating View Scheme
参考文献
McKittrick, Brian; Failli, Amedeo; Steffan, Robert J.; Soll, Richard M.; Hughes, Philip; et al.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2151 - 2163
