4,5-二甲基-1,2-苯二胺合成路线 （共 140 条）
参考文献
Saeed, Ali A. H.; Ebraheem, Ebraheem K.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1739 - 1740
反应条件
alumina supported sulfuric acid in ethanol
T=30°C; 3 h; Green chemistry;
参考文献
Pramanik, Amit; Roy, Rimi; Khan, Sagar; Ghatak, Avishek; Bhar, Sanjay
Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1771 - 1777
反应条件
hydrogenchloride in water
17 h; Heating / reflux;
参考文献
AnorMED, Inc.
Patent: US6750348 B1, 2004 ;
Location in patent: Page column 74 ;
US 6750348 B1
反应条件
in ethanol
Ambient temperature;
参考文献
Wilson; Hunt
Australian Journal of Chemistry, 1983 , vol. 36, # 11 p. 2317 - 2325
反应条件
2: SOCl2
View Scheme
参考文献
Mamalis et al.
Journal of the Chemical Society, 1950 , p. 1600,1602
反应条件
1: ethanol; water / 3 h / |Reflux
2: hydrogen bromide; bromine; acetic acid / water / 4.5 h / 0 - 23 °C
3: 0.5 h / 180 °C / |Microwave irradiation
4: sodium hydrogencarbonate / methanol / 72 h / 23 °C
View Scheme
参考文献
Hershberger, Paul M.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Divlianska, Daniela B.; Correa, Ricardo G.; Pinkerton, Anthony B.; Reed, John C.; Roth, Gregory P.
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 900 - 907
反应条件
1: ethanol; water / 3 h / |Reflux
2: hydrogen bromide; bromine; acetic acid / water / 4.5 h / 0 - 23 °C
3: 0.5 h / 180 °C / |Microwave irradiation
4: butan-1-ol / 15 h / 115 °C
View Scheme
参考文献
Hershberger, Paul M.; Peddibhotla, Satyamaheshwar; Sessions, E. Hampton; Divlianska, Daniela B.; Correa, Ricardo G.; Pinkerton, Anthony B.; Reed, John C.; Roth, Gregory P.
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 900 - 907
参考文献
Kalyanam, Nagabhushanam; Manjunatha, Sulur G
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 7 p. 415 - 420
参考文献
Gazit, Aviv; App, Harald; McMahon, Gerald; Chen, Jefferey; Levitzki, Alexander; Bohmer, Frank D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2170 - 2177
参考文献
Addison, Anthony W.; Burke, Philip J.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 803 - 805
