4,5-二甲基-1,2-苯二胺合成路线 （共 140 条）
反应条件
1: 98 percent / 2N HCl / 0.5 h / 100 °C 2: 93 percent / POCl3 / 4 h / Heating View Scheme
参考文献
Bhat, Ajita; Chang, Hui-Min; Wallace, Lane J.; Weinstein, David M.; Shams, Gamal; Garris, Cynthia C.; Hill, Ronald A.
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 3 p. 271 - 282
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
aluminum oxide T=20°C; 0.166667 h; neat (no solvent);
参考文献
Li, Jun; Jiang, Dan-Na; Chen, Jiu-Xi; Liu, Miao-Chang; Ding, Jin-Chang; Wu, Hua-Yue
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 403 - 406
反应条件
silica sulfuric acid; PEG-400 T=120°C; 2 h;
参考文献
Huang, Tieqiang; Jiang, Danna; Chen, Jiuxi; Gao, Wenxia; Ding, Jinchang; Wu, Huayue
Synthetic Communications, 2011 , vol. 41, # 22 p. 3334 - 3343
反应条件
1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide T=90°C; 4 h;
参考文献
Qi, Chaorong; Jiang, Huanfeng; Huang, Liangbin; Chen, Zhengwang; Chen, Huoji
Synthesis, 2011 , # 3 art. no. F17110SS, p. 387 - 396
反应条件
potassium hydroxide T=400 - 600°C;
参考文献
Mamedov, Vakhid A.; Zhukova, Nataliya A.; Syakaev, Victor V.; Gubaidullin, Aidar T.; Beschastnova, Tat'Yana N.; Adgamova, Dil'Bar I.; Samigullina, Aida I.; Latypov, Shamil K.
Tetrahedron, 2013 , vol. 69, # 4 p. 1403 - 1416
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
Oxonereg; in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Saha, Biswajit; Sharma, Sunil; Kundu, Bijoy
Synthetic Communications, 2007 , vol. 37, # 19 p. 3455 - 3470
反应条件
boric acid in acetic acid T=20°C; 2 h; Inert atmosphere;
参考文献
Chen, Shuai; Hossain, Mohammad S.; Foss, Frank W.
Organic Letters, 2012 , vol. 14, # 11 p. 2806 - 2809
参考文献
Tishler et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 2165,2167
