N1,N4-二(苯基甲基)-1,4-丁烷二胺合成路线 （共 4 条）
反应条件
sodium tetrahydroborate in ethanol T=20°C; 2 h;
参考文献
Hwang, Jong Yeon; Kim, Hee-Young; Jo, Suyeon; Park, Eunjung; Choi, Jihyun; Kong, Sunju; Park, Dong-Sik; Heo, Ja Myung; Lee, Jong Seok; Ko, Yoonae; Choi, Inhee; Cechetto, Jonathan; Kim, Jaeseung; Lee, Jinhwa; No, Zaesung; Windisch, Marc Peter
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 315 - 325
反应条件
1: in methanol 2 h; 2: With sodium tetrahydroborate in methanol T=0 - 25°C; 2 h; 3: With sodium hydroxide; acetic acid more than 3 stages;
参考文献
GILEAD SCIENCES, INC.
Patent: WO2008/10921 A2, 2008 ;
Location in patent: Page/Page column 294 ;
反应条件
1: 90 percent / 0.25 h 2: 75 percent / NaBH4 / methanol / 0.33 h / Heating View Scheme
参考文献
Niitsu, Masaru; Samejima, Keijiro
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 3 p. 1032 - 1038
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Veith,H.J. et al.
Helvetica Chimica Acta, 1971 , vol. 54, p. 653 - 680
