3-(2-硝基乙基)吲哚合成路线 （共 23 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=20°C; 6 h;
参考文献
Vo, Quan V.; Trenerry, Craige; Rochfort, Simone; Wadeson, Jenny; Leyton, Carolina; Hughes, Andrew B.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 2 p. 856 - 864
参考文献
AMGEN INC.
Patent: WO2007/62175 A2, 2007 ;
Location in patent: Page/Page column 32 ;
WO 2007/062175 A2
反应条件
sodium methylate 24 h;
参考文献
Hermkens; Van Maarseveen; Cobben; Ottenheijm; Kruse; Scheeren
Tetrahedron, 1990 , vol. 46, # 3 p. 833 - 846
反应条件
1: AcONH4 / 100 °C 2: NaBH4, SiO2 / CHCl3; propan-2-ol View Scheme
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
in xylene T=90 - 100°C; 5 h;
参考文献
Thompson, Andrew M.; Fry, David W.; Kraker, Alan J.; Denny, William A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 5 p. 598 - 609
参考文献
Warner-Lambert
Patent: US5464861 A1, 1995 ;
US 5464861 A
反应条件
phosphoric acid; α-chymotrypsin in N,N-dimethyl-formamide 14 h;
参考文献
West, J. Blair; Hennen, William J.; Lalonde, James L.; Bibbs, Jeffrey A.; Zhong, Ziyang; Meyer Jr., Edgar F.; Wong, Chi-Huey
Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5313 - 5320
反应条件
in benzene 20 h; Ambient temperature;
参考文献
Ranganathan, Darshan; Rao, C.Bhushan; Ranganathan, Subramania; Mehrotra, Ashok K.; Iyengar, Radha
Journal of Organic Chemistry, 1980 , vol. 45, # 7 p. 1185 - 1189
反应条件
1: trichlorophosphate / 0 - 20 °C 2: ammonium acetate / 1.5 h / 105 °C 3: sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Guo, Xiaoke; Yang, Qian; Xu, Jing; Zhang, Li; Chu, Hongxi; Yu, Peng; Zhu, Yingying; Wei, Jinglian; Chen, Weilin; Zhang, Yaozhong; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6466 - 6476
反应条件
hydrogenchloride; sodium hydroxide
参考文献
Lyttle; Weisblat
Journal of the American Chemical Society, 1955 , vol. 77, p. 5747
