2-(4-(((2-(3-氟-4-(三氟甲基)苯基)-4-甲基噻唑-5-基)甲基)硫代)-2-甲基苯氧基)乙酸合成路线 （共 10 条）
反应条件
1: 99 percent / Cs2CO3 / acetonitrile / 16 h / 20 °C 2: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating 3: NaOCH3; MeOH 4: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 5: 47 percent / various solvent(s) / 253 °C 6: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 7: Cs2CO3 / acetonitrile / 16 h / 20 °C 8: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: Cs2CO3 / acetonitrile / 16 h / 20 °C 2: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 2: 47 percent / various solvent(s) / 253 °C 3: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 4: Cs2CO3 / acetonitrile / 16 h / 20 °C 5: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating 2: NaOCH3; MeOH 3: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 4: 47 percent / various solvent(s) / 253 °C 5: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 6: Cs2CO3 / acetonitrile / 16 h / 20 °C 7: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: NaOCH3; MeOH 2: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 3: 47 percent / various solvent(s) / 253 °C 4: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 5: Cs2CO3 / acetonitrile / 16 h / 20 °C 6: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 47 percent / various solvent(s) / 253 °C 2: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 3: Cs2CO3 / acetonitrile / 16 h / 20 °C 4: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 2: Cs2CO3 / acetonitrile / 16 h / 20 °C 3: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: Cs2CO3 / acetonitrile / 16 h / 20 °C 2: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 100 percent / MeSO2Cl; Et3N / CH2Cl2 / 0 °C 2: Cs2CO3 / acetonitrile / 16 h / 20 °C 3: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 °C 2: 100 percent / MeSO2Cl; Et3N / CH2Cl2 / 0 °C 3: Cs2CO3 / acetonitrile / 16 h / 20 °C 4: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
