[4-甲基-2-(4-(三氟甲基)苯酚)-1,3-噻唑-5-基]甲醇合成路线 （共 15 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1.66667 h; 2: With water in tetrahydrofuran
参考文献
KALYPSYS, INC.
Patent: WO2005/60958 A1, 2005 ;
Location in patent: Page/Page column 115-116 ;
WO 2005/060958 A1
反应条件
ethyl 4-METHYL-2- [4- (TRIFLUOROMETHYL) PHENYL]-THIAZOLE-5- carboxylate in tetrahydrofuran T=0 - 25°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/785 A2, 2003 ;
Location in patent: Page 43 ;
WO 2004/000785 A2
反应条件
1: With borane-THF in tetrahydrofuran 3 h; Heating / reflux; 2: With water in tetrahydrofuran
参考文献
EP1586573 A1, ;
Page/Page column 15 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
WO2005/51945 A1, ;
Page/Page column 88 ;
WO 2005/051945 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl acetamide T=140°C; Stille reaction; 18 h;
参考文献
Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; De Lera, Angel R.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 49 - 54
反应条件
1: ethanol / 24 h / Heating 2: 80.2 g / LiAlH4 / tetrahydrofuran / 1.3 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 4 p. 685 - 695
反应条件
1: 87 percent / Pd(PPh3)4; K2CO3 / toluene / 100 °C 2: 70 percent / PdCl2(PPh3)2 / N,N-dimethyl-acetamide / 18 h / 140 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 1 p. 49 - 54
反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran 2.1: 87 percent / Pd(PPh3)4; K2CO3 / toluene / 100 °C 3.1: 70 percent / PdCl2(PPh3)2 / N,N-dimethyl-acetamide / 18 h / 140 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 1 p. 49 - 54
反应条件
1: 68 percent / Pd2(dba)3; AsPh3 / 1-methyl-pyrrolidin-2-one / 24 h / 70 °C 2: 70 percent / PdCl2(PPh3)2 / N,N-dimethyl-acetamide / 18 h / 140 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 1 p. 49 - 54
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane T=0°C;
参考文献
KALYPSYS, INC.
Patent: WO2005/60958 A1, 2005 ;
Location in patent: Page/Page column 116 ;
WO 2005/060958 A1
