乙基2-[3-氟-(三氟甲基)苯基]-4-甲基-噻唑-5-羧酸酯合成路线 （共 4 条）
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 °C 2: 100 percent / MeSO2Cl; Et3N / CH2Cl2 / 0 °C 3: Cs2CO3 / acetonitrile / 16 h / 20 °C 4: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 °C 2: 100 percent / MeSO2Cl; Et3N / CH2Cl2 / 0 °C View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C;
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
