2-[3-氟-4-(三氟甲基)苯基]-4-甲基-5-羟基甲基噻唑合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C;
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 100 percent / MeSO2Cl; Et3N / CH2Cl2 / 0 °C 2: Cs2CO3 / acetonitrile / 16 h / 20 °C 3: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane T=0°C;
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
