2-[2-氟-4-(三氟甲基)苯基]-4-甲基-1,3-噻唑-5-羧酸乙酯合成路线 （共 3 条）
反应条件
1: ethanethiolic acid; 2-fluoro-4-(trifluoromethyl)benzonitrile With boron trifluoride diethyl etherate in toluene T=20°C; 4 h; 2: ethyl 2-chloro-3-oxobutanoate in toluene T=100°C; 14 h;
参考文献
WO2003/74504 A2, ;
Page/Page column 34-35 ;
反应条件
in toluene T=100°C; 16 h;
参考文献
Brown, Andrew D.; Davis, Roman D.; Fitzgerald, Russ N.; Glover, Bobby N.; Harvey, Kim A.; Jones, Lynda A.; Liu, Bing; Patterson, Daniel E.; Sharp, Matthew J.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 297 - 302
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-15 - -10°C; 2 h;
参考文献
Brown, Andrew D.; Davis, Roman D.; Fitzgerald, Russ N.; Glover, Bobby N.; Harvey, Kim A.; Jones, Lynda A.; Liu, Bing; Patterson, Daniel E.; Sharp, Matthew J.
Organic Process Research and Development, 2009 , vol. 13, # 2 p. 297 - 302
