1,4-二噁螺[4.5]癸烷-8-乙酸甲酯合成路线 （共 4 条）
反应条件
Celite; hydrogen; palladium 10 on activated carbon in ethyl acetate 16 h;
参考文献
Rew, Yosup; McMinn, Dustin L.; Wang, Zhulun; He, Xiao; Hungate, Randall W.; Jaen, Juan C.; Sudom, Athena; Sun, Daqing; Tu, Hua; Ursu, Stefania; Villemure, Elisia; Walker, Nigel P.C.; Yan, Xuelei; Ye, Qiuping; Powers, Jay P.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1797 - 1801
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 1.2: 19 h / 20 °C 2.1: hydrogen / palladium 10 on activated carbon / ethanol / 24 h / 20 °C View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2471777 A1, 2012 ;
反应条件
lithium aluminium tetrahydride; Celite in tetrahydrofuran
T=-78 - 20°C; 1 h;
参考文献
ALLERGAN, INC.
Patent: WO2003/99795 A1, 2003 ;
Location in patent: Page 81 - 86 ;
WO 03/099795 A1
反应条件
hydrogenchloride in water; acetone
T=20°C; 15 h;
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2471777 A1, 2012 ;
Location in patent: Page/Page column 10 ;
