2-甲基 2-甲基吡咯烷-1,2-二羧酸-1-叔丁酯合成路线 （共 3 条）
反应条件
1: pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester With lithium diisopropyl amide in tetrahydrofuran; n-heptane T=-78°C; 3 h; 2: methyl iodide in tetrahydrofuran; n-heptane T=0°C; 2.5 h;
参考文献
SUNOVION PHARMACEUTICALS INC.; HARDY, Larry, Wendell; HEFFERNAN, Michele, L., R.; WU, Frank, Xinhe; SPEAR, Kerry, L.; SARASWAT, Lakshmi, D.
Patent: WO2011/75699 A2, 2011 ;
Location in patent: Page/Page column 177 ;
WO 2011/075699 A1
反应条件
1: methyl (2S)-N-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.333333 h; 2: methyl iodide in tetrahydrofuran; hexane 1.5 h; cooling; Further stages.;
参考文献
Clive, Derrick L. J.; Li, Zhiyong; Yu, Maolin
Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5608 - 5617
反应条件
1: With sodium hydroxide in methanol; water 5 h; Reflux; 2: With hydrogenchloride in water pH=3;
参考文献
Tetrahedron, , vol. 66, # 19 p. 3525 - 3536
