2-甲基-4-(2-甲基苯甲酰氨基)苯甲酸合成路线 (共 6 条)
反应条件
1: 2-methyl-benzoic acid m-toluidide With AlCl3, aluminium chloride in dichloromethane T=3°C; 0.166667 h; 2: oxalyl dichloride in dichloromethane T=2 - 7°C; 5 h; 3: With hydrogenchloride; sodium hydroxide; water Product distribution / selectivity; more than 3 stages;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2007/26971 A2, 2007 ;
Location in patent: Page/Page column 38-39 ;
反应条件
1: With sodium hypochlorite; water in isopropyl alcohol T=5 - 60°C; 1 h; 2: With hydrogenchloride in water T=20°C; Product distribution / selectivity;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2007/26971 A2, 2007 ;
Location in patent: Page/Page column 36-37 ;
反应条件
1: With sodium hypochlorite; water in isopropyl alcohol T=10 - 20°C; 0.5 - 1 h; 2: With hydrogenchloride in water; isopropyl alcohol Product distribution / selectivity;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2007/26971 A2, 2007 ;
Location in patent: Page/Page column 39 ;
反应条件
1: With sodium hydroxide; water in methanol T=60 - 76°C; 4 h; 2: With hydrogenchloride in methanol; water T=60 - 76°C; pH=1; Product distribution / selectivity;
参考文献
OTSUKA PHARMACEUTICAL CO., LTD.
Patent: WO2007/26971 A2, 2007 ;
Location in patent: Page/Page column 37-38 ;
反应条件
1: With palladium diacetate; tributyl-amine; caesium acetate; triphenylphosphine in N,N-dimethyl-formamide T=120°C; carbonylation; Hydrolysis; 3 h; 2: With sodium hydroxide in N,N-dimethyl-formamide; toluene T=20°C; 0.5 h;
参考文献
Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-ichi
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2493 - 2495
反应条件
caesium acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide Heating;
参考文献
Torisawa, Yasuhiro; Furuta, Takuya; Nishi, Takao; Aki, Shinji; Minamikawa, Jun-ichi
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6455 - 6458