(2R)-4-氨基-2-羟基丁酸合成路线 (共 10 条)
反应条件
hydrogen; palladium on activated charcoal in methanol P=760 Torr; 48 h;
参考文献
Srairi, Driss; Maurey, Georges
Bulletin de la Societe Chimique de France, 1987 , # 2 p. 297 - 301
参考文献
Woo,P.W.K. et al.
Tetrahedron Letters, 1971 , p. 2617 - 2620
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Fowden
Biochemical Journal, 1956 , vol. 64, p. 323,330
反应条件
(i) (racemate resolution using dehydroabiethylamine), (ii) aq. HCl; Multistep reaction;
参考文献
Naito; Nakagawa; Abe; Toda; Fujisawa
Journal of Antibiotics, 1973 , vol. 26, # 5 p. 297 - 301
反应条件
(i) Ac2O, Py, (ii) H2, aq. HCl, EtOH, PtO2, (iii) ion-exchange resin <H+ form>; Multistep reaction;
参考文献
Yoneta; Shibahara; Fukatsu; Seki
Bulletin of the Chemical Society of Japan, 1978 , vol. 51, # 11 p. 3296 - 3297
反应条件
hydrogenchloride in ethanol 48 h; Ambient temperature;
参考文献
Ringdahl; Craig
1980 , vol. 34, # 10 B p. 731 - 733
反应条件
(i) Ac<sub>2</sub>O, Py, (ii) H<sub>2</sub>, aq. HCl, EtOH, PtO<sub>2</sub>, (iii) ion-exchange resin <H<sup>+</sup> form>; Multistep reaction; <br />
参考文献
Yoneta; Shibahara; Fukatsu; Seki Bulletin of the Chemical Society of Japan, 1978 , vol. 51, # 11 p. 3296 - 3297
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>; <a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a> <b>in</b> <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />P=760 Torr; 48 h; <br />
参考文献
Srairi, Driss; Maurey, Georges Bulletin de la Societe Chimique de France, 1987 , # 2 p. 297 - 301
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '906771', constants.ctx, '0')">sodium nitrite</a> <br /> <br />
参考文献
Woo,P.W.K. et al. Tetrahedron Letters, 1971 , p. 2617 - 2620 Fowden Biochemical Journal, 1956 , vol. 64, p. 323,330
反应条件
<b>With</b> <a href="#" onclick="return RXDsubstances(event, this, '29438767', constants.ctx, '0')">wildtype taurine dioxygenase</a> <br /> Enzymatic reaction; enantioselective reaction; <br />
参考文献
Wetzl, Dennis; Bolsinger, Jennifer; Nestl, Bettina M.; Hauer, Bernhard ChemCatChem, 2016 , vol. 8, # 7 p. 1361 - 1366
反应条件
(i) (racemate resolution using dehydroabiethylamine), (ii) aq. HCl; Multistep reaction; <br />
参考文献
Naito; Nakagawa; Abe; Toda; Fujisawa Journal of Antibiotics, 1973 , vol. 26, # 5 p. 297 - 301