1: 3-amino-5-tert-butyl-2-(p-tolyl)-2H-pyrazole hydrochloride With sodium hydroxide in water; ethyl acetate T=0°C; 1 h; 2: β,β,β-trichloroethoxycarbonylchloride in ethyl acetate T=20°C; 2 h;

sodium hydroxide in water; ethyl acetate

1.1: methanol / Reflux 2.1: sodium hydroxide / ethyl acetate; water / 1 h / 0 °C 2.2: 2 h / 20 °C View Scheme

1.1: methanol / Reflux 2.1: sodium hydroxide / ethyl acetate; water / 1 h / 0 °C 2.2: 2 h / 20 °C View Scheme

1: 4-nitro-1-(2-morpholinethoxy)naphthalene With hydrogen; 5 palladium on charcoal in tetrahydrofuran; methanol; dimethyl sulfoxide T=20°C; 2: (5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester With N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=60°C;

N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide; ethyl acetate

N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=60°C; 5 h;

in dimethyl sulfoxide T=100°C; 0.5 h; microwave irradiation;