2-甲基-2-丙基(4-乙炔基苯基)氨基甲酸酯合成路线 （共 3 条）
反应条件
trimethylsilylazide; silver carbonate in dimethyl sulfoxide T=80°C; 24 h;
参考文献
Shen, Tao; Wang, Teng; Qin, Chong; Jiao, Ning
Angewandte Chemie - International Edition, 2013 , vol. 52, # 26 p. 6677 - 6680
Angew. Chem., 2013 , vol. 125, # 26 p. 6809 - 6612,4
反应条件
1: 65 percent / Pd(PPh3)4; CuI; DIEA / tetrahydrofuran
2: HCl / dioxane
View Scheme
参考文献
Xue, Chu-Biao; He, Xiaohua; Roderick, John; Corbett, Ronald L.; Duan, James J.-W.; Liu, Rui-Qin; Covington, Maryanne B.; Newton, Robert C.; Trzaskos, James M.; Magolda, Ronald L.; Wexler, Ruth R.; Decicco, Carl P.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4293 - 4297
反应条件
Multi-step reaction with 3 steps 1.1: sodium carbonate / tetrahydrofuran; water / 18 h / 0 - 20 °C2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 0 - 20 °C3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 0 °C3.2: 0 - 20 °C
参考文献
Neelarapu, Raghupathi; Holzle, Denise L.; Velaparthi, Subash; Bai, He; Brunsteiner, Michael; Blond, Sylvie Y.; Petukhov, Pavel A. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4350 - 4364
