5-氨基-2-甲基噻唑-4-羧酸乙酯合成路线 （共 6 条）
反应条件
1: With Lawesson's reagent in toluene T=70°C; 16 h; 2: With hydrogenchloride in water; toluene
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/14895 A1, 2004 ;
Location in patent: Page 79 ;
WO 2004/014895 A1
反应条件
Lawesson's reagent in tetrahydrofuran 2 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 55, # 14 p. 4484 - 4487
反应条件
hydrogen sulfide in pyridine 48 h;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 20, # 4 p. 275 - 278
反应条件
in benzene 24 h; Heating;
参考文献
Golankiewicz, Bozenna; Januszczyk, Piotr; Gdaniec, Maria; Kosturkiewicz, Zofia
Tetrahedron, 1985 , vol. 41, # 24 p. 5989 - 5994
反应条件
1: acetonitrile / 0.75 h / Heating 2: 1.7 g / H2S (gas) / pyridine / 48 h View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 20, # 4 p. 275 - 278
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 19, p. 119 - 123
