2-苯基-5-氨基噻唑-4-羧酸乙酯合成路线 （共 9 条）
反应条件
Lawesson's reagent in pyridine 15 h; Reflux;
参考文献
GENENTECH, INC.; Hodges, Alastair James; Matteucci, Mizio; Sharpe, Andrew; Sun, Minghua; Wang, Xiaojing; Tsui, Vickie H.
Patent: US2013/79321 A1, 2013 ;
Location in patent: Paragraph 0223; 0224 ;
参考文献
Genentech, Inc.; Burch, Jason; Sun, Minghua; Wang, Xiaojing; Blackaby, Wesley; Hodges, Alastair James; Sharpe, Andrew
Patent: US2014/88117 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
in toluene 17 h; Heating;
参考文献
Corrao, Stephanie L.; Macielag, Mark J.; Turchi, Ignatius J.
Journal of Organic Chemistry, 1990 , vol. 55, # 14 p. 4484 - 4487
反应条件
1: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 20 °C 2: Lawesson's reagent / pyridine / 15 h / Reflux View Scheme
参考文献
GENENTECH, INC.; Hodges, Alastair James; Matteucci, Mizio; Sharpe, Andrew; Sun, Minghua; Wang, Xiaojing; Tsui, Vickie H.
Patent: US2013/79321 A1, 2013 ;
反应条件
1: 88 percent / aqueous ammonia / 0.5 h / Ambient temperature 2: 66 percent / 2,4-bis(methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (Lawesson's reagent) / tetrahydrofuran / 2 h / Heating 3: 87 percent / toluene / 17 h / Heating View Scheme
参考文献
Corrao, Stephanie L.; Macielag, Mark J.; Turchi, Ignatius J.
Journal of Organic Chemistry, 1990 , vol. 55, # 14 p. 4484 - 4487
反应条件
1: 66 percent / 2,4-bis(methoxyphenyl)-1,3-dithia-2,4-diphosphetane 2,4-disulfide (Lawesson's reagent) / tetrahydrofuran / 2 h / Heating 2: 87 percent / toluene / 17 h / Heating View Scheme
参考文献
Corrao, Stephanie L.; Macielag, Mark J.; Turchi, Ignatius J.
Journal of Organic Chemistry, 1990 , vol. 55, # 14 p. 4484 - 4487
反应条件
1: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 35 °C 2: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 20 °C 3: Lawesson's reagent / pyridine / 15 h / Reflux View Scheme
参考文献
GENENTECH, INC.; Hodges, Alastair James; Matteucci, Mizio; Sharpe, Andrew; Sun, Minghua; Wang, Xiaojing; Tsui, Vickie H.
Patent: US2013/79321 A1, 2013 ;
反应条件
1: sodium hydrogencarbonate / water 2: sodium hydrogencarbonate / water 3: pyridine View Scheme
参考文献
Genentech, Inc.; Burch, Jason; Sun, Minghua; Wang, Xiaojing; Blackaby, Wesley; Hodges, Alastair James; Sharpe, Andrew
Patent: US2014/88117 A1, 2014 ;
参考文献
Tamura,Y. et al.
Chemical and Pharmaceutical Bulletin, 1971 , vol. 19, p. 119 - 123
