1-(4-甲氧苯基)-2-硝基乙烯合成路线 （共 57 条）
反应条件
1: 1.) lithium isopropylcyclohexylamide / 1.) THF, hexane, -78 deg C, 1 h, 2.) -78 deg C, 2 h 50 min 2: 15 percent / conc. H2SO4 / methanol / 0.08 h / -35 °C 3: 84 percent / LiAlH4 / tetrahydrofuran / 0.17 h / Ambient temperature 4: 79 percent / 8percent aq. HCl / diethyl ether 5: 47 percent / KOH / aq. ethanol / 0.58 h / Heating View Scheme
参考文献
Forbes, Craig P.; Schoeman, Wentzel J.; Strauss, Heinrich F.; Venter, Elize M. M.; Wenteler, George L.; Wiechers, Adriaan
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 906 - 910
反应条件
dihydrogen peroxide; triethylamine
参考文献
Karmarkar, Pradeep G.; Thakar, Alka A.; Wadia, Murzban S.
Tetrahedron Letters, 1981 , vol. 22, # 24 p. 2301 - 2302
反应条件
ethanol; hydrazine hydrate
参考文献
Musante
Gazzetta Chimica Italiana, 1937 , vol. 67, p. 579,586
反应条件
acetic acid; lithium chloride; palladium dichloride T=25°C; 20 h;
参考文献
Ohe, Toshiyuki; Uemura, Sakae
Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 7 p. 1423 - 1431
参考文献
Itoh, Kazuyoshi; Ishida, Hideaki; Chikashita, Hidenori
Chemistry Letters, 1982 , p. 1117 - 1118
反应条件
1: sodium tetrahydroborate; silica gel / dichloromethane; isopropyl alcohol / 0.33 h / 20 °C
2: potassium fluoride; dimethylammonium chloride / toluene / 24 h / Reflux
3: iron; acetic acid / 2 h / 100 °C
View Scheme
参考文献
Kodukulla; Trivedi; Vora; Mathur
Synthetic Communications, 1994 , vol. 24, # 6 p. 819 - 832
反应条件
titanium tetrachloride; zinc
1.) methylene chloride, -40 deg C -> room temperature, 2.) room temperature, 1 h; Yield given. Multistep reaction;
参考文献
Kim, Dae Young; Oh, Dong Young
Synthetic Communications, 1987 , vol. 17, # 8 p. 953 - 958
反应条件
1: 70 percent / H2 / carbon palladium 10percent / 85 °C / 37503 Torr
2: 67 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
View Scheme
参考文献
Hocquaux; Marcot; Redeuilh; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 4 p. 319 - 329
反应条件
didodecanoyl peroxide in 1,2-dichloro-ethane
Heating;
参考文献
Garcia-Torres, Alejandro; Cruz-Almanza, Rymundo; Miranda, Luis D.
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2085 - 2088
反应条件
1: 97 percent / KHMDS; 18-crown-6 / tetrahydrofuran / -78 °C
2: 91 percent / MP-TsOH; methanol
3: hydrogen / Pd/C / 37503 Torr
View Scheme
参考文献
Buchanan, David J.; Dixon, Darren J.; Scott, Mark S.; Laine, Dramane I.
Tetrahedron Asymmetry, 2004 , vol. 15, # 2 p. 195 - 197
