3-氧-3,4-二氢-2H-1,4-苯并恶嗪-6-磺酰氯合成路线 (共 4 条)
反应条件
chlorosulfonic acid T=0 - 10°C; 1.33333 h;
参考文献
Memory Pharmaceuticals Corporation
Patent: US2010/16297 A1, 2010 ;
Location in patent: Page/Page column 28 ;
US 20100016297 A1
反应条件
1: sodium hydrogencarbonate; N-benzyl-N,N,N-triethylammonium chloride / chloroform / 16.33 h / 0 - 60 °C 2: chlorosulfonic acid / 2 h / 0 - 20 °C View Scheme
参考文献
WO2012/88314 A1, ;
WO 2012/088314 A1
反应条件
(i) (diazotation), (ii) SO2, CuCl; Multistep reaction;
参考文献
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, , vol. 270, p. 1601 - 1604
反应条件
hydrogenchloride; tin in 1,4-dioxane
2 h; Reflux;
参考文献
PROGENRA INC.; CAO, Ping; WEINSTOCK, Joseph; KINGSBURY, William, D.; LEACH, Craig, A.; KIZHAKKETHIL-GEORGE, Suresh, Kumar; NICHOLSON, Benjamin
Patent: WO2010/114881 A1, 2010 ;
Location in patent: Page/Page column 112 ;