lithium hydroxide in tetrahydrofuran; water T=20°C; 2 h;

copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in anhydrous propionitrile T=110°C; 4 h;

IrradiationCo-60 γ-rays;

1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-78°C; 0.333333 h; Cooling with acetone-dry ice; 2: 6-(hydroxymethyl)nicotinonitrile in dichloromethane T=-78°C; 2 h; Cooling with acetone-dry ice; 3: With ammonium chloride; triethylamine more than 3 stages;