2’,3’,5’-三乙酰肌苷合成路线 （共 38 条）
反应条件
1: 96 percent / SOCl2 / dimethylformamide; CHCl3 2: 51 percent / NaOMe / methanol 3: 15 percent / CaCO3 / ethanol / 21 h / Heating View Scheme
参考文献
Patching, Simon G.; Baldwin, Stephen A.; Baldwin, Alexander D.; Young, James D.; Gallagher, Maurice P.; Henderson, Peter J. F.; Herbert, Richard B.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 462 - 470
反应条件
1: 93 percent / chloromethylenedimethyliminium chloride / CHCl3 / 4 h / Heating 2: ethanol; H2O / 12 h / 20 °C View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
1: 96 percent / SOCl2 / dimethylformamide; CHCl3 2: 51 percent / NaOMe / methanol View Scheme
参考文献
Kusachi, Shozo; Thompson, Robert D.; Bugni, William J.; Yamada, Nobuyuki; Olsson, R. A.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1636 - 1643
反应条件
methanol; water; triethylamine T=20°C; 24 h;
参考文献
Meier, Lidiane; Monteiro, Gustavo C.; Baldissera, Rodrigo A.M.; Sa, Marcus Mandolesi
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 5 p. 859 - 866
反应条件
methanol; water; triethylamine T=71°C; Microwave irradiation;
参考文献
Meier, Lidiane; Monteiro, Gustavo C.; Baldissera, Rodrigo A.M.; Sa, Marcus Mandolesi
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 5 p. 859 - 866
反应条件
1: 48 percent / POCl3 / N,N-diethylaniline / 0.17 h / Heating 2: 67.3 percent / H2 / MgO / 10percent Pd-C / methanol / 4 h / Ambient temperature 3: 76 percent / NH3 / methanol / 30 h / 0 °C View Scheme
参考文献
Gupta, P. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 7 p. 534 - 537
反应条件
1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 16 h / 0 °C / |Reflux 2: ammonia / methanol 3: triethylamine / ethanol / 24 h / 78 °C View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
1: SOCl2 / dimethylformamide; CHCl3 2: 78 percent / NaOAc, H2 / 5 percent Pd/C / methanol / 24 h / 2068.6 Torr / Ambient temperature View Scheme
参考文献
Gupta, P. K.; Bhakuni, D. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 7 p. 534 - 537
反应条件
1: thionyl chloride / chloroform; N,N-dimethyl-formamide / 16 h / 0 °C / |Reflux 2: ammonia / methanol 3: triethylamine / ethanol / 24 h / 78 °C View Scheme
参考文献
Anglin, Justin L.; Deng, Lisheng; Yao, Yuan; Cai, Guobin; Liu, Zhen; Jiang, Hong; Cheng, Gang; Chen, Pinhong; Song, Yongcheng; Dong, Shuo
Journal of Medicinal Chemistry, 2012 , vol. 55, # 18 p. 8066 - 8074,9
反应条件
1.1: 96 percent / SOCl2 / dimethylformamide; CHCl3 2.1: 51 percent / NaOMe / methanol 3.1: dimethylformamide / 0 °C 3.2: 42 percent / Et3N / dimethylformamide / 0 °C View Scheme
参考文献
Hoebartner, Claudia; Kreutz, Christoph; Flecker, Elke; Ottenschlaeger, Elke; Pils, Werner; Grubmayr, Karl; Micura, Ronald
Monatshefte fur Chemie, 2003 , vol. 134, # 6 p. 851 - 873
