2’,3’,5’-三乙酰肌苷合成路线 （共 38 条）
反应条件
Yield given. Multistep reaction;
参考文献
Itaya, Taisuke; Matsumoto, Hiroo; Watanabe, Tomoko
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 86 - 90
反应条件
1: 77 percent / i-Pr2NEt / CH2Cl2 / 1.08 h / 0 °C 2: aq. NH3 / methanol / 20 °C 3: aq. NaOH / Heating View Scheme
参考文献
Kohyama, Naoki; Yamamoto, Yukio
Synthesis, 2003 , # 17 p. 2639 - 2642
反应条件
1: 100 percent / phosphoryl trichloride, N,N-dimethylaniline / 0.12 h / 115 °C
2: 87 percent / triethylamine / methanol / 0.5 h / Ambient temperature
3: 97 percent / ammonia / methanol / Ambient temperature
4: 84 percent / toluene-4-sulphonic acid monohydrate / tetrahydrofuran / 1 h / 50 °C
5: 88 percent / 3-chloroperbenzoic acid / CH2Cl2 / 2.5 h / -5 °C
6: 70 percent / N,N-di-isopropylethylamine / N,N-dimethyl-acetamide / 28 h / 70 - 75 °C
7: 0.65 g / aq. formic acid / 3 h / Ambient temperature
8: hydrogen / palladium on carbon / ethanol; acetic acid; H2O / 2 h
View Scheme
参考文献
Buck, Ildiko M.; Reese, Colin B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 11 p. 2937 - 2942
反应条件
1: 100 percent Chromat. / I2; PPh3; EtN(i-Pr)2 / CH2Cl2 / 0.83 h / 20 °C
2: 81 mg / NaOMe / methanol / 10 h
View Scheme
参考文献
Lin, Xiaoyu; Robins, Morris J.
Organic Letters, 2000 , vol. 2, # 22 p. 3497 - 3499
反应条件
1.1: 85 percent / N,N-dimethylaniline; phosphorus oxychloride / 0.22 h / Heating
2.1: diisopropylethylamine / ethanol / 18 h / Heating
2.2: 58 percent / NH3 / methanol / 0 - 20 °C
3.1: 100 percent / H2; acetic acid / Pd/C / methanol; H2O / 3 h
View Scheme
参考文献
Middleton, Richard J.; Briddon, Stephen J.; Cordeaux, Yolande; Yates, Andrew S.; Dale, Clare L.; George, Michael W.; Baker, Julian G.; Hill, Stephen J.; Kellam, Barrie
Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 782 - 793
反应条件
o-nitrobenzenesulfonyl peroxy radical
参考文献
Park, Min Young; Yang, Seung Gak; Kim, Yong Hae
Heteroatom Chemistry, 2002 , vol. 13, # 5 p. 431 - 436
反应条件
1: I2; PPh3; EtN(i-Pr)2 / toluene / 0.83 h / 95 °C
2: 141 mg / NH3 / methanol / 2 h / 0 °C
3: 92 percent / NaH / dimethylformamide; various solvent(s) / 40 h / 20 °C
View Scheme
参考文献
Lin, Xiaoyu; Robins, Morris J.
Organic Letters, 2000 , vol. 2, # 22 p. 3497 - 3499
反应条件
1: 100 percent Chromat. / I2; PPh3; EtN(i-Pr)2 / CH2Cl2 / 1 h / 20 °C
2: 131 mg / NaOMe / methanol
View Scheme
参考文献
Lin, Xiaoyu; Robins, Morris J.
Organic Letters, 2000 , vol. 2, # 22 p. 3497 - 3499
