barium dihydroxide

1: ethyl N-(2-propenyl)glycinate With sodium hydroxide in 1,4-dioxane; methanol; water Hydrolysis; 0.75 h; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium hydroxide in 1,4-dioxane; methanol; water Acylation; pH=8.5 - 9.0; 16 h; Further stages.;

ammonium hydroxide in ethanol 5 h; Heating; Yield given;

1: 10percent aq. NaOH / 5 h / Heating 2: conc. aq. HCl, aq. NaNO2 / Ambient temperature 3: trifluoroacetic anhydride / ethyl acetate / 1 h / 0 °C View Scheme

Multi-step reaction with 2 steps 1: 38.4 g / NEt3 / methanol / 1 h / 60 °C2: 82 percent / DIBAH / CH2Cl2 / -80 - -65 °C