反应条件
1: 95 percent / tetrahydrofuran / 1 h / -78 °C
2: 97 percent / Jones reagent / diethyl ether / 2 h / 25 °C
3: 1.) n-butyllithium, 2.) cuprous bromide dimethylsulfide complex / 1.) THF, -78 deg C, 1.5 h; 2.) ether, -50 deg C, 1 h, 3.) -50 deg C, 1 min, glacial acetic acid in methanol
4: 92 percent / NaBH4 / methanol / 0.25 h / -40 °C
5: 1.) NaHSO4; 2.) LiOH / 1.) dimethoxy ethane-water, O deg C, 3 min; 2.) 25 deg C, 1 hr
View Scheme
参考文献
Corey, E. J.; Kyler, Keith; Raju, Natarajan
Tetrahedron Letters, 1984 , vol. 25, # 45 p. 5115 - 5118
