3-氨其噻吩-2-甲酸乙酯合成路线 （共 8 条）
反应条件
sodium ethanolate in ethanol
参考文献
Abdillahi, Ismail; Kirsch, Gilbert
Synthesis, 2010 , # 9 art. no. Z01210SS, p. 1428 - 1430
参考文献
Eisai Co., Ltd.
Patent: US6340759 B1, 2002 ;
Location in patent: Example 259 ;
反应条件
1: 88 percent / 1.5 h / Heating 2: 73 percent / NaOEt / ethanol / 8 h / Heating 3: 1) 20percent aq. NaOH, 2) conc. HCl / 1) heating, 2 h, 2) heating 4: 50 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Chadwick, Nigel; Keenan, Guy J.
Journal of Chemical Research, Miniprint, 1980 , # 1 p. 113 - 126
反应条件
1.1: K2CO3 / toluene / Heating 2.1: KH / toluene; dimethylformamide / 80 °C 2.2: H2O / dimethylsulfoxide / 140 °C View Scheme
参考文献
Brault, Laurent; Migianu, Evelyne; Neguesque, Adrien; Battaglia, Eric; Bagrel, Denyse; Kirsch, Gilbert
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 757 - 763
参考文献
Whang, Jina; Song, Yang-Heon
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 3 p. 603 - 607
反应条件
1: 88 percent / 1.5 h / Heating
2: 73 percent / NaOEt / ethanol / 8 h / Heating
3: 1) 20percent aq. NaOH, 2) conc. HCl / 1) heating, 2 h, 2) heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Chadwick, Nigel; Keenan, Guy J.
Journal of Chemical Research, Miniprint, 1980 , # 1 p. 113 - 126
反应条件
1: 88 percent / 1.5 h / Heating
2: 73 percent / NaOEt / ethanol / 8 h / Heating
3: 1) 20percent aq. NaOH, 2) conc. HCl / 1) heating, 2 h, 2) heating
4: 9 percent / POCl3 / 3 h / Heating
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Chadwick, Nigel; Keenan, Guy J.
Journal of Chemical Research, Miniprint, 1980 , # 1 p. 113 - 126
反应条件
1: 88 percent / 1.5 h / Heating
2: 73 percent / NaOEt / ethanol / 8 h / Heating
3: 1) 20percent aq. NaOH, 2) conc. HCl / 1) heating, 2 h, 2) heating
4: 9 percent / POCl3 / 3 h / Heating
5: diethyl ether
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Chadwick, Nigel; Keenan, Guy J.
Journal of Chemical Research, Miniprint, 1980 , # 1 p. 113 - 126
