1: With acetic acid in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: With sodium tris(acetoxy)borohydride in tetrahydrofuran 1 h; 3: With sodium hydroxide in water pH=13; 0.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2010/190763 A1, 2010 ;
Location in patent: Page/Page column 84 ;
US 20100190763 A1