4-(1-苄基哌啶-4-基)丁-1-醇合成路线 （共 13 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Reflux;
参考文献
Bolea, Irene; Juarez-Jimenez, Jordi; De Los Rios, Cristobal; Chioua, Mourad; Pouplana, Ramon; Luque, F. Javier; Unzeta, Mercedes; Marco-Contelles, Jose; Samadi, Abdelouahid
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8251 - 8270
反应条件
1: 63 percent / NaOEt / ethanol / 1.75 h / 5 - 20 °C 2: 97 percent / H2 / 10 percent Pd/C / ethanol / 8 h / 20 °C 3: 86 percent / NaI; Na2CO3 / dimethylformamide / 6 h / 20 °C 4: 96 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 11 p. 1611 - 1622
反应条件
1: 97 percent / H2 / 10 percent Pd/C / ethanol / 8 h / 20 °C 2: 86 percent / NaI; Na2CO3 / dimethylformamide / 6 h / 20 °C 3: 96 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 11 p. 1611 - 1622
反应条件
1.1: NaH / tetrahydrofuran / 1 h / 20 °C 1.2: tetrahydrofuran / 20 h / 20 °C 2.1: pyridinium chloroformate; Celite / CH2Cl2 / 4 h / 20 °C 3.1: CH2Cl2 / 2 h / 20 °C 4.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 4.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 5.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 6.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 7.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
反应条件
1.1: 12.88 g / dioxane; H2O / 10 h / Heating 2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 2.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 3.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 4.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 5.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
反应条件
1.1: pyridinium chloroformate; Celite / CH2Cl2 / 4 h / 20 °C 2.1: CH2Cl2 / 2 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 3.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 4.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 5.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 6.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
反应条件
1.1: CH2Cl2 / 2 h / 20 °C 2.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 2.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 3.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 4.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 5.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 1.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 2.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 3.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 4.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
反应条件
1.1: Et3N / tetrahydrofuran / 4 h / 20 °C 2.1: 12.88 g / dioxane; H2O / 10 h / Heating 3.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 3.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 4.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 5.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 6.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
反应条件
1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C 1.2: 59 percent / tetrahydrofuran / 0.5 h / Heating 2.1: 95 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C 3.1: 67 percent / Na; liq. NH3 / 2 h / -78 - -30 °C 4.1: 430 mg / LiAlH / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 49, # 6 p. 1079 - 1088
