2,4-二羟基-6-甲基苯甲酸甲酯合成路线 （共 72 条）
反应条件
sodium hydrogencarbonate in dichloromethane T=25°C; Methylation; 12 h;
参考文献
Nicolaou; Rodriguez, Rosa Maria; Mitchell, Helen J.; Suzuki, Hideo; Fylaktakidou, Konstantina C.; Baudoin, Olivier; Van Delft, Floris L.
Chemistry - A European Journal, 2000 , vol. 6, # 17 p. 3095 - 3115
反应条件
n-butyllithium; sodium hydride in tetrahydrofuran 12 h; Heatingother temperature, solvents, time; Product distribution;
参考文献
Barrett, Anthony G. M.; Morris, Timothy M.; Barton, Derek H. R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2272 - 2277
反应条件
aluminium trichloride in dichloromethane T=0 - 20°C;
参考文献
Mondal, Mukulesh; Puranik, Vedavati G.; Argade, Narshinha P.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2068 - 2076
反应条件
Armillaria mellea iterative type I polyketide synthase ArmB, N-terminal hexahistidine-tagged protein in aq. phosphate buffer pH=7.4; 20 h; Enzymatic reaction;
参考文献
Lackner, Gerald; Bohnert, Markus; Wick, Jonas; Hoffmeister, Dirk
Chemistry and Biology, 2013 , vol. 20, # 9 p. 1101 - 1106
反应条件
1: acetoacetic acid methyl ester With sodium hydride in tetrahydrofuran T=-5 - 0°C; 0.5 h; 2: 4-methylene-oxetan-2-one in tetrahydrofuran T=-5 - 20°C; Product distribution / selectivity;
参考文献
Resverlogix Corp.
Patent: WO2008/92231 A1, 2008 ;
Location in patent: Page/Page column 94-97 ;
WO 2008/092231 A1
反应条件
sodium acetate in methanol
参考文献
Hill, James E.; Harris, Thomas M.
Synthetic Communications, 1982 , vol. 12, # 8 p. 621 - 626
反应条件
1: With sodium hydride in tetrahydrofuran T=0°C; Inert atmosphere; 2: With n-butyllithium in tetrahydrofuran T=-78 - 0°C; 17 h; Inert atmosphere;
参考文献
Wilson, Zoe E.; Brimble, Margaret A.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 6 p. 1284 - 1286
反应条件
1: 80 percent / NaClO2; aq. NaH2PO4 / dimethylsulfoxide / 12 h / 0 - 25 °C 2: 90 percent / K2CO3 / acetone / 24 h / 25 °C View Scheme
参考文献
Nicolaou; Mitchell, Helen J.; Suzuki, Hideo; Rodriguez, Rosa Maria; Baudoin, Olivier; Fylaktakidou, Konstantina C.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 22 p. 3334 - 3339
反应条件
1.1: AlCl3; HCl / 3 h / 0 °C 1.2: 92 percent / H2O / 0.5 h / 0 - 100 °C 2.1: 80 percent / NaClO2; NaH2PO4 / dimethylsulfoxide / 12 h / 0 °C 3.1: 90 percent / NaHCO3 / CH2Cl2 / 12 h / 25 °C View Scheme
参考文献
Nicolaou; Mitchell, Helen J.; Suzuki, Hideo; Rodriguez, Rosa Maria; Baudoin, Olivier; Fylaktakidou, Konstantina C.
Angewandte Chemie - International Edition, 1999 , vol. 38, # 22 p. 3334 - 3339
反应条件
in dichloromethane T=100°C; 10 h; Molecular sieveInert atmospheresealed tube;
参考文献
Basset, Jean-Francois; Leslie, Colin; Hamprecht, Dieter; White, Andrew J.P.; Barrett, Anthony G.M.
Tetrahedron Letters, 2010 , vol. 51, # 5 p. 783 - 785
