2-氨基-5-氟苯甲酸甲酯合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated carbon in methanol P=760.051 Torr; 120 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2005/28474 A2, 2005 ;
Location in patent: Page/Page column 201-202 ;
WO 2005/028474 A2
反应条件
1: With hydrogenchloride T=100°C; 2: With water; potassium carbonate in dichloromethane
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2009/21696 A1, 2009 ;
Location in patent: Page/Page column 65-66 ;
WO 2009/021696 A1
反应条件
in tetrahydrofuran; methanol T=20°C; 3 h;
参考文献
WO2007/9774 A1, ;
Page/Page column 22 ;
WO 2007/009774 A1
反应条件
1: N-methyl-N-nitroso-p-toluene-sulphonamide With potassium hydroxide in diethyl ether; water 2: 2-amino-5-fluoro-benzoic acid in diethyl ether 1 h;
参考文献
Schuler, Elisabeth; Juanico, Nacho; Teixido, Jordi; Michelotti, Enrique L.; Borrell, Jose I.
Heterocycles, 2006 , vol. 67, # 1 p. 161 - 173
反应条件
1: thionyl chloride 3: platinum; ethanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1165
反应条件
2: platinum; ethanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 66, p. 1165
参考文献
Thorat, Dhanaji Achyutrao; Doddareddy, Munikumar Reddy; Seo, Seon Hee; Hong, Tae-Joon; Cho, Yong Seo; Hahn, Ji-Sook; Pae, Ae Nim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1593 - 1597
反应条件
1: phenol / 150 °C 2: trichlorophosphate View Scheme
参考文献
Thorat, Dhanaji Achyutrao; Doddareddy, Munikumar Reddy; Seo, Seon Hee; Hong, Tae-Joon; Cho, Yong Seo; Hahn, Ji-Sook; Pae, Ae Nim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1593 - 1597
