3,5-二氟-4-甲氧基苯甲酸合成路线 （共 8 条）
反应条件
1: in toluene 6 h; Reflux; 2: With hydrogenchloride in water
参考文献
EP2179651 A1, ;
Page/Page column 49 ;
参考文献
Journal of the American Chemical Society, , vol. 62, p. 350,353
Journal of the American Chemical Society, , vol. 63, p. 2204,2208
反应条件
1: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide 2: sodium hydroxide; bromine / 1,4-dioxane; water View Scheme
参考文献
US6265426 B1, ;
US 6265426 B1
反应条件
1: thionyl chloride; diethyl ether; ammonia 2: aqueous alkaline sodium hypobromite View Scheme
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
反应条件
thionyl chloride; diethyl ether; ammonia
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
反应条件
1: thionyl chloride; diethyl ether; ammonia
2: aqueous alkaline sodium hypobromite
3: aqueous H2SO4; aqueous CuSO4-solution; xylene / Diazotization
View Scheme
参考文献
Niemann; Benson; Mead
Journal of the American Chemical Society, 1941 , vol. 63, p. 2204,2208
反应条件
thionyl chloride in toluene
2 h; Reflux;
参考文献
Japan Tobacco Inc.
Patent: US2008/64871 A1, 2008 ;
Location in patent: Page/Page column 44 ;
反应条件
in chloroform; N,N-dimethyl-formamide
参考文献
Japan Tobacco Inc.
Patent: US2008/305169 A1, 2008 ;
