(S)-(-)-4-异丁基氧氮杂环戊烷-2,5-二酮合成路线 （共 34 条）
反应条件
1: triethylamine / acetonitrile / 4 h / 20 °C
2: H2 / Pd / acetic acid; 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Oya, Masanao; Takahashi, Tomoko
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 9 p. 2705 - 2707
反应条件
(i) aq. K2B4O7, (ii) /BRN= 82617/, aq. KOH, (iii) H+; Multistep reaction;
参考文献
Hirschmann,R. et al.
Journal of Organic Chemistry, 1967 , vol. 32, p. 3415 - 3425
反应条件
borate buffer; sulfuric acid
1.) acetone, -10 deg C, 5 min, 2.) 15 min; Multistep reaction;
参考文献
Masquelier; Baurain; Trouet
Journal of Medicinal Chemistry, 1980 , vol. 23, # 11 p. 1166 - 1170
反应条件
1: triethylamine / CHCl3; tetrahydrofuran / 1) 3 h, - 70 deg C, 2) 30 min, r. t.
2: 79 percent / toluene / 12 h / Heating
View Scheme
参考文献
Schoellkopf, Ulrich; Groth, Ulrich; Gull, Martin-Reinhold; Nozulak, Joachim
Liebigs Annalen der Chemie, 1983 , # 7 p. 1133 - 1151
