3-苯并[b]噻吩-2-丙醇合成路线 （共 3 条）
反应条件
1: With methanol; lithium borohydride in diethyl ether T=0 - 20°C; 3 h; 2: With sodium hydroxide in diethyl ether; water 1 h;
参考文献
ALLERGAN, INC.
Patent: US2006/111430 A1, 2006 ;
Location in patent: Page/Page column 22 ;
US 20060111430 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 18 h; Inert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB
Patent: WO2009/153536 A1, 2009 ;
Location in patent: Page/Page column 66 ;
WO 2009/153536 A1
反应条件
sodium acetate; toluene-4-sulfonic acid hydrazide in ethylene glycol dimethyl ether; water 2.5 h; Reflux;
参考文献
Cho, Hidetsura; Iwama, Yusuke; Sugimoto, Kenji; Mori, Seiji; Tokuyama, Hidetoshi
Journal of Organic Chemistry, 2010 , vol. 75, # 3 p. 627 - 636
